A wide range of investigations, from laboratory research, to animal feeding studies, to human supplementation trials, have confirmed the health benefits and traditional use of tongkat ali root extract. Laboratory evidence shows that eurycoma peptides stimulate release of free testosterone from its binding proteins and improve overall hormone profiles. More than a dozen rodent feeding studies have demonstrated improved sex drive, balanced hormonal profiles, and enhanced physical function. Human supplementation trials show a clear indication of reduced fatigue, heightened energy and mood, and greater sense of well-being in subjects consuming tongkat ali root extracts.

   It is important to note that the majority of these studies, and all of the human supplementation trials, have been conducted on specific hot-water-extracts of Eurycoma longifolia(which is the traditional Malaysian preparation).

   In conclusion, tongkat ali, used for centuries in traditional medicine systems of Southeast Asia for treating lethargy, low libido, depression, and fatigue, appears to have significant potential for restoring hormone balance (cortisol/testosterone) and improving psychological mood state in humans exposed to various modern stressors, including aging, dieting, and exercise stress.